Novel mechanisms of chronic inflammation in secondary progressive multiple sclerosis
نویسندگان
چکیده
منابع مشابه
Defining secondary progressive multiple sclerosis.
A number of studies have been conducted with the onset of secondary progressive multiple sclerosis as an inclusion criterion or an outcome of interest. However, a standardized objective definition of secondary progressive multiple sclerosis has been lacking. The aim of this work was to evaluate the accuracy and feasibility of an objective definition for secondary progressive multiple sclerosis,...
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Chemokines are 8 ± 12 kd chemoattractant cytokines characterized by a four cysteine motif (Luster, 1998; Ransohoff et al, 1996; Schall, 1994; Taub, 1996). The presence or absence of an intervening amino acid(s) (X) between the N terminal cysteines de®nes the CXC/CX3C and CC families, respectively. A third family, C chemokines, lacks an N terminal cysteine but is otherwise homologous. It was ori...
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Progressive multiple sclerosis (MS) is characterized clinically by the accumulation of neurological disability without unequivocal recovery. Understanding the mechanisms that determine entering in this stage of the disease is a great challenge in order to identify potential therapeutic targets. Recent advances in defining more accurately the progressive phenotype of MS, have concluded that diff...
متن کاملThe natural history of secondary progressive multiple sclerosis.
BACKGROUND The onset of secondary progression is a pivotal event in the course of relapsing-remitting (RR) multiple sclerosis (MS). Patients with secondary progressive MS (SPMS) experience continuous worsening of symptoms independent of the occurrence of relapses. Possible risk factors associated with the onset of SPMS remain under investigated in natural history studies of MS disease course. ...
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BACKGROUND AND PURPOSE Beta-interferons (IFNβ) are the most widely prescribed drugs for patients with multiple sclerosis (MS). However, whether or not treatment with IFNβ can delay secondary progressive MS (SPMS) onset remains unknown. Our aim was to examine the association between IFNβ exposure and SPMS onset in patients with relapsing-remitting MS (RRMS). METHODS A retrospective cohort stud...
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ژورنال
عنوان ژورنال: Clinical and Experimental Neuroimmunology
سال: 2018
ISSN: 1759-1961
DOI: 10.1111/cen3.12437